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Abnormality of neutrophils

MedGen UID:
488900
•Concept ID:
C0427515
•
Finding
Synonyms: Abnormality of neutrophil; Abnormality of polymorphonuclear neutrophils; Neutrophil abnormality
SNOMED CT: Neutrophil abnormality (250274006)
 
HPO: HP:0001874

Definition

A neutrophil abnormality. [from HPO]

Conditions with this feature

Pelger-Huët anomaly
MedGen UID:
10617
•Concept ID:
C0030779
•
Disease or Syndrome
An autosomal dominant inherited condition caused by mutations in the lamin B receptor gene. It is characterized by defects in the neutrophil lobulation, resulting in the presence of dumbbell-shaped neutrophils with bilobed nuclei in the peripheral blood smear.
See: Condition Record
Pelger-Huët anomaly

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.
Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.
Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
COPD and biologic treatment: state of the art.
Ferri S, Paoletti G, Pelaia C, Heffler E, Canonica GW, Puggioni F
Curr Opin Allergy Clin Immunol 2023 Aug 1;23(4):309-318. Epub 2023 Jun 20 doi: 10.1097/ACI.0000000000000920. PMID: 37357768

Recent clinical studies

Etiology

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.
Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D
Cell Stem Cell 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. PMID: 37267914
Neutrophil and T Cell Functions in Patients with Congenital Heart Diseases: A Review.
Yuki K, Koutsogiannaki S
Pediatr Cardiol 2021 Oct;42(7):1478-1482. Epub 2021 Jul 20 doi: 10.1007/s00246-021-02681-3. PMID: 34282478Free PMC Article
Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China.
Jie LS, Yu Y, Ping ZJ, Dong XX, Ping CX, Chao H, Li Y, Jing Y, Ling TY, Yan JM, Peng L
Medicine (Baltimore) 2020 Nov 6;99(45):e22980. doi: 10.1097/MD.0000000000022980. PMID: 33157941Free PMC Article
Novel proresolving aspirin-triggered DHA pathway.
Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA
Chem Biol 2011 Aug 26;18(8):976-87. doi: 10.1016/j.chembiol.2011.06.008. PMID: 21867913Free PMC Article
Epidermolysis bullosa acquisita localized to the face.
Choi GS, Lee ES, Kim SC, Lee S
J Dermatol 1998 Jan;25(1):19-22. doi: 10.1111/j.1346-8138.1998.tb02339.x. PMID: 9519604

Diagnosis

Neutrophil Reactivity Intensity and misclassification of immature granulocytes.
Wiwe EF, Kofoed IK, Dufréchou MJF, Philipsen JP, Lemvig B, Rasmussen KL, Smith J, Hillig T
Int J Lab Hematol 2024 Apr;46(2):312-321. Epub 2023 Nov 20 doi: 10.1111/ijlh.14204. PMID: 37985128
Primary cicatricial alopecia: Other lymphocytic primary cicatricial alopecias and neutrophilic and mixed primary cicatricial alopecias.
Bolduc C, Sperling LC, Shapiro J
J Am Acad Dermatol 2016 Dec;75(6):1101-1117. doi: 10.1016/j.jaad.2015.01.056. PMID: 27846945
A Review and Proposed Approach to the Neutrophilic Dermatoses of Childhood.
Webb K, Hlela C, Jordaan HF, Suliman S, Scriba T, Lipsker D, Scott C
Pediatr Dermatol 2015 Jul-Aug;32(4):437-46. Epub 2015 Feb 26 doi: 10.1111/pde.12502. PMID: 25727235
Neutrophilic dermatoses: part II.
Razera F, Olm GS, Bonamigo RR
An Bras Dermatol 2011 Mar-Apr;86(2):195-209; quiz 210-1. doi: 10.1590/s0365-05962011000200001. PMID: 21603801
Neutrophil abnormalities.
Boxer LA
Pediatr Rev 2003 Feb;24(2):52-62. doi: 10.1542/pir.24-2-52. PMID: 12563039

Therapy

Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China.
Jie LS, Yu Y, Ping ZJ, Dong XX, Ping CX, Chao H, Li Y, Jing Y, Ling TY, Yan JM, Peng L
Medicine (Baltimore) 2020 Nov 6;99(45):e22980. doi: 10.1097/MD.0000000000022980. PMID: 33157941Free PMC Article
Neutrophil-rich Variant of Persistent Bullous Grover's Disease.
Togo S, Ozawa K, Fujii A, Tanii T, Tsuruta D, Ishii N, Hashimoto T, Tadokoro T, Isei T
Acta Derm Venereol 2019 Dec 1;99(13):1282-1283. doi: 10.2340/00015555-3316. PMID: 31513276
Epidermolysis bullosa acquisita localized to the face.
Choi GS, Lee ES, Kim SC, Lee S
J Dermatol 1998 Jan;25(1):19-22. doi: 10.1111/j.1346-8138.1998.tb02339.x. PMID: 9519604
Cytokines: a new immunotherapy.
Cairo MS
Clin Perinatol 1991 Jun;18(2):343-59. PMID: 1879112
Clinical studies of granulocyte colony stimulating factor (G-CSF).
Scarffe JH, Kamthan A
Cancer Surv 1990;9(1):115-30. PMID: 1703454

Prognosis

Neutrophil Reactivity Intensity and misclassification of immature granulocytes.
Wiwe EF, Kofoed IK, Dufréchou MJF, Philipsen JP, Lemvig B, Rasmussen KL, Smith J, Hillig T
Int J Lab Hematol 2024 Apr;46(2):312-321. Epub 2023 Nov 20 doi: 10.1111/ijlh.14204. PMID: 37985128
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China.
Jie LS, Yu Y, Ping ZJ, Dong XX, Ping CX, Chao H, Li Y, Jing Y, Ling TY, Yan JM, Peng L
Medicine (Baltimore) 2020 Nov 6;99(45):e22980. doi: 10.1097/MD.0000000000022980. PMID: 33157941Free PMC Article
Preoperative cell line abnormalities in children with chronic cardiac disease: Symbol or surrogate?
Alsoufi B
J Card Surg 2020 Mar;35(3):524-525. Epub 2020 Jan 23 doi: 10.1111/jocs.14437. PMID: 31971289
Epidermolysis bullosa acquisita localized to the face.
Choi GS, Lee ES, Kim SC, Lee S
J Dermatol 1998 Jan;25(1):19-22. doi: 10.1111/j.1346-8138.1998.tb02339.x. PMID: 9519604

Clinical prediction guides

Neutrophil Reactivity Intensity and misclassification of immature granulocytes.
Wiwe EF, Kofoed IK, Dufréchou MJF, Philipsen JP, Lemvig B, Rasmussen KL, Smith J, Hillig T
Int J Lab Hematol 2024 Apr;46(2):312-321. Epub 2023 Nov 20 doi: 10.1111/ijlh.14204. PMID: 37985128
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
Preoperative cell line abnormalities in children with chronic cardiac disease: Symbol or surrogate?
Alsoufi B
J Card Surg 2020 Mar;35(3):524-525. Epub 2020 Jan 23 doi: 10.1111/jocs.14437. PMID: 31971289
Neutrophils in critical illness.
McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324
Neutrophil dysfunction in Crohn's disease.
Segal AW, Loewi G
Lancet 1976 Jul 31;2(7979):219-21. doi: 10.1016/s0140-6736(76)91024-2. PMID: 59239

Recent systematic reviews

Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia.
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554Free PMC Article
Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy.
Zhao J, Dong Y, Zhang Y, Wang J, Wang Z
Adv Drug Deliv Rev 2022 Dec;191:114585. Epub 2022 Oct 21 doi: 10.1016/j.addr.2022.114585. PMID: 36273512
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.
Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Ann Rheum Dis 2022 May;81(5):601-613. Epub 2022 Jan 27 doi: 10.1136/annrheumdis-2021-221814. PMID: 35086813Free PMC Article
Hematological findings and complications of COVID-19.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA
Am J Hematol 2020 Jul;95(7):834-847. Epub 2020 May 23 doi: 10.1002/ajh.25829. PMID: 32282949Free PMC Article

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